League Leaders - Offense
| Passing Yards | Complete List | |
Matthew Stafford
|
1. Matthew Stafford, LAR | 5975 |
| 2. Joe Burrow, CIN | 5316 | |
| 3. Kyler Murray, ARI | 5068 | |
| 4. Trevor Lawrence, JAX | 4879 | |
| 5. Mac Jones, NE | 4843 | |
| Rushing Yards | Complete List | |
Nick Chubb
|
1. Nick Chubb, CLE | 1622 |
| 2. David Montgomery, CHI | 1377 | |
| 3. Javonte Williams, DEN | 1348 | |
| 4. Jonathan Taylor, IND | 1341 | |
| 5. Austin Ekeler, LAC | 1294 | |
| Receiving Yards | Complete List | |
Cooper Kupp
|
1. Cooper Kupp, LAR | 2119 |
| 2. Kayshon Boutte, HOU | 1839 | |
| 3. Darren Waller, LV | 1652 | |
| 4. Kendrick Bourne, NE | 1650 | |
| 5. CeeDee Lamb, DAL | 1594 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin Bush
|
1. Devin Bush, PIT | 77 |
| 2. Myles Jack, PIT | 76 | |
| 3. Christian Harris, HOU | 66 | |
| 4. Roquan Smith, CHI | 64 | |
| 5. Levi Wallace, PIT | 62 | |
| Sacks | Complete List | |
Osa Odighizuwa
|
1. Osa Odighizuwa, DAL | 17 |
| 2. Payton Wilson, ARI | 14 | |
| 3. Trey Hendrickson, CIN | 14 | |
| 4. Nick Bosa, SF | 14 | |
| 5. Kwity Paye, IND | 13 | |
| Interceptions | Complete List | |
Xavien Howard
|
1. Xavien Howard, MIA | 18 |
| 2. Antonio Johnson, CAR | 12 | |
| 3. Juan Thornhill, KC | 12 | |
| 4. Trevon Diggs, DAL | 11 | |
| 5. Kevin Byard, TEN | 11 | |