| Player Rushing Statistics | |||||||||
| Name | Att | Yds | Avg | Lng | Fmb | 20+ | Btk | TD | |
| 1. Taj Buchanon, SF | 20 | 180 | 9.0 | 59 | 0 | 2 | 3 | 1 | |
| 2. Jerome Curtis, GB | 20 | 179 | 9.0 | 48 | 0 | 3 | 4 | 3 | |
| 3. De'Von Achane, MIA | 19 | 135 | 7.1 | 75 | 0 | 1 | 3 | 3 | |
| 4. Jahmyr Gibbs, NE | 6 | 96 | 16.0 | 67 | 3 | 2 | 3 | 2 | |
| 5. Anthony Richardson, MIA | 11 | 92 | 8.4 | 49 | 0 | 1 | 0 | 1 | |
| 6. Dameon Pierce, HOU | 13 | 76 | 5.8 | 16 | 0 | 0 | 3 | 0 | |
| 7. Isiah Pacheco, KC | 10 | 74 | 7.4 | 35 | 0 | 1 | 1 | 1 | |
| 8. Jonathan Taylor, CHI | 12 | 51 | 4.3 | 13 | 0 | 0 | 4 | 1 | |
| 9. James Cook, DET | 12 | 39 | 3.3 | 23 | 1 | 2 | 2 | 1 | |
| 10. Kevin Jowers, DET | 2 | 28 | 14.0 | 18 | 0 | 0 | 1 | 0 | |
| 11. Malik Willis, SF | 3 | 25 | 8.3 | 18 | 0 | 0 | 0 | 0 | |
| 12. Chris Booth, CHI | 1 | 25 | 25.0 | 25 | 0 | 1 | 2 | 0 | |
| 13. Earl Samuel, DET | 2 | 21 | 10.5 | 28 | 0 | 1 | 9 | 0 | |
| 14. Justin Fields, CHI | 5 | 21 | 4.2 | 24 | 0 | 1 | 0 | 0 | |
| 15. Michael Devlin, NE | 1 | 6 | 6.0 | 6 | 0 | 0 | 1 | 0 | |
| 16. Tyrus Griffey, KC | 1 | 4 | 4.0 | 4 | 0 | 0 | 0 | 0 | |
| 17. Patrick Mahomes, KC | 1 | 4 | 4.0 | 4 | 0 | 0 | 0 | 1 | |
| 18. C.J. Stroud, HOU | 2 | 4 | 2.0 | 2 | 0 | 0 | 0 | 1 | |
| 19. Trey Lance, DET | 1 | 1 | 1.0 | 1 | 0 | 0 | 0 | 1 | |
| 20. Geno Smith, SF | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | |